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EC number: 201-627-4
CAS number: 85-73-4
healthy wistar albino rats of both sex (ranging b.wt 200±20 gm) selected
for study after acclimatization. Approximate 10 percent back skin of
total body surface area was prepared 24 hrs prior to application of test
compound. The test compound CAS No. 85-73-4was applied dermally at the
dose level of 2000 mg/kg b.wt to each animal. The treated animals were
observed for clinical signs of intoxication and mortality at different
time interval for a period of 14 days. The body weight of each rat was
observed on day 0 (pre treatment), 7thand 14th(post
treatment). The necropsy was performed on all animals which was died
during the study or were sacrificed at termination of the study.
was no incidence of mortality recorded after administration of test
compound 85-73-4 at the dose level of 2000 mg/kg b.wt.
test compound CAS No. 85-73-4did not elicit any clinical signs of
toxicity during the entire observation period. No skin reaction was
observed after 24thhrs. of patch removal.
body weight of each animal recorded on day 0, 7thand 14thshowed
normal increase in weight was recorded.
obtained from present investigation can be concluded that the test
compound CAS No. 85-73-4is acutely non toxic at the tested dose level of
2000 mg/kg b.wt in Wistar albino rats when applied by dermal route.The
acute dermal LD50of test compound CAS No. 85-73-4found to be
more than 2000mg/kg b.wt. (> 2000 mg/kg b.wt.).
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