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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication peer reviewed.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1993

Materials and methods

Type of study / information:
In vitro hepatotoxicity (cytotoxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetic acid
EC Number:
200-927-2
EC Name:
Trichloroacetic acid
Cas Number:
76-03-9
Molecular formula:
C2HCl3O2
IUPAC Name:
trichloroacetic acid
Details on test material:
- Name of test material (as cited in study report): trichloroacetic acid (TCA)
- Analytical purity: 99%

Results and discussion

Any other information on results incl. tables

Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular glutathione (GSH) status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.

Applicant's summary and conclusion

Conclusions:
It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.
Executive summary:

In the present study the in vitro cytotoxicity of trichloroacetic acid was determined in hepatocyte suspensions prepared from naive and clofibric acid-pretreated male Sprague-Dawley rats and B6C3F1 mice. Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular GSH status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.