Reaction mass of 3-[(2-aminoethyl)ammonio]propane-1-sulfonate and 3,3'-(ethane-1,2-diyldiammonio)dipropane-1-sulfonate and ethane-1,2-diamine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Report date:

2008

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Due to the high water solubility of the test substance and the already attained precision the water solubility was only estimated visually and not determined by the full flask method.The experimental estimation was performed with solutions of the test substance in water between
72 % (w/w) and 91 % (w/w). The "solutions" were checked visually for undissolved particles.

GLP compliance:

yes

Type of method:

other: Visually

Test material

Test material information

Constituent 1

Reference substance name:

3-[(2-aminoethyl)amino]propane-1-sulfonic acid

Cas Number:

14235-54-2

Molecular formula:

C5H14N2O3S

IUPAC Name:

3-[(2-aminoethyl)amino]propane-1-sulfonic acid

Details on test material:

- Physical state: solid
- Analytical purity: approx. 95 %
- Impurities (identity and concentrations): water approx 5%
- Lot/batch No.: 06060423/101
- Stability under test conditions: stable
- Storage condition of test material: room temperature in the dark

Results and discussion

Water solubility

Water solubility:

> 1 000 g/L

Temp.:

21 °C

Remarks on result:

other: The determination of the pH was not possible due to the high viscosity of the solutions.

Details on results:

The temperature during the test was 21 °C.
The determination of the pH was not possible due to the high viscosity of the solutions.
The water solubility of "3-[(2-aminoethyl)ammonio]propane-1-sulfonate" was estimated to:
>91 % (w/w) at 21 °C. The concentration is equivalent to >1000 g/L.
The test substance is miscible at any concentration with water.

Any other information on results incl. tables

Results

mass of the test substance	added water	concentration		annotations
(g)	(g)	(g/L)	% (w/w)
1.3	0.5	--	72	soluble; highly viscous liquid
3.0	1.0	--	75
3.2	0.5	--	86
4.0	0.4	>1000*	91

* The volume of the solution was approximately 3.8 mL.

Due to the high water solubility of the test substance and the already attained precision the water solubility was only estimated visually and not determined by the full flask method.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): miscible
The water solubility of "3-[(2-aminoethyl)ammonio]propane-1-sulfonate" was estimated to:
>91 % (w/w) at 21 °C. The concentration is equivalent to >1000 g/L.
The test substance is miscible at any concentration with water.

The pH of the solutions were 2.2 at 10 °C and 2.1 at 20 °C.

Executive summary:

The water solubility of the test substance was estimated visually according to OECD- and EU-methods.

The water solubility of "3-[(2-aminoethyl)ammonio]propane-1-sulfonate" was estimated to: >91 % (w/w) at 21 °C. The concentration is equivalent to >1000 g/L. The test substance is miscible at any concentration with water.

The determination of the pH was not possible due to the high viscosity of the solutions.