Reaction mass of Methacryloxypropyl (tris(trialkylsiloxy)silylethyl dimethylsiloxy) silane and oligomers

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Reason / purpose for cross-reference:

data waiving: supporting information

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 105 (Water Solubility)

Version / remarks:

A method has been proposed by Thomas and Burosse to improve the current OECD 105 Water Solubility test design for poorly water soluble liquids by incorporating a portion of another OECD guideline (OECD 123) This method is very similar to a previous method used by Varaprath et al to determine the solubility of several poorly soluble permethylsiloxanes. The test article was anticipated to be so poorly soluble, that the current methods listed in OECD 105 are inappropriate

Deviations:

yes

Remarks:

Minor deviations were noted but these did not have an impact on the overall study

GLP compliance:

yes

Type of method:

slow-stirring method

Partition coefficient type:

octanol-water

Key result

Type:

log Pow

Remarks on result:

not determinable because of methodological limitations

Remarks:

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.

Details on results:

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.

The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Conclusions:

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Executive summary:

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Description of key information

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.