Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-846-2 | CAS number: 75-18-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature Documentation insufficient for assessment Original reference not available
Data source
Reference
- Reference Type:
- publication
- Title:
- Dimethyl sulphide
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, 17(4), pp 365-368
Materials and methods
- Principles of method if other than guideline:
- Data not available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl sulphide
- EC Number:
- 200-846-2
- EC Name:
- Dimethyl sulphide
- Cas Number:
- 75-18-3
- Molecular formula:
- C2H6S
- IUPAC Name:
- (methylsulfanyl)methane
- Details on test material:
- Dimethyl sulphide (no other information available)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- data not available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- data not available
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 months
- Frequency of treatment:
- 6 h/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 and 25 mg/m3
Basis:
no data
- No. of animals per sex per dose:
- 15 males and 15 females
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
- Positive control:
- data not available
Examinations
- Observations and examinations performed and frequency:
- data not available
- Sacrifice and pathology:
- data not available
- Other examinations:
- data not available
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
25 mg/m3 : Decrease in weight gain, increase in heart
weight, disorders of corticosteroid distribution in the
adrenal tissue, a decrease in oxygen consumption and carbon
dioxide elimination, decreases in catalase activity and the methaemoglobin and phospholipid levels in the blood, and increases in pyruvic acid, lactic acid and thiol groups in whole blood and in tissue homogenates. Increased cholesterol levels in the blood serum.
5 mg/m3 : temporary changes (no detail available)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
