Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 401-700-2 | CAS number: 3100-36-5 CYCLOHEXADECENON; CYCLOHEXADECENONE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key in vivo skin irritation study in rabbits according to OECD guideline 404 and GLP, no skin irritation was observed under the conditions of the study.
In the key in vivo eye irritation study in rabbits according to OECD guideline 405, the test item was found to be non-irritating to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No mentioning of clinical and body weight observations, irritation readings only after 24 and 72 hours
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- No mentioning of clinical and body weight observations, irritation readings only after 24 and 72 hours
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Albino rabbits
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Not specified
- Weight at study initiation: 3.0 kg (average)
- Housing: Individually
- Diet: Ad libitum (Altromin standard diet for rabbits)
- Water: Ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 2
- Humidity (%): 50-60
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From day 0 to day 7 - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Remarks:
- Shaved and scarified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- The test item was used undiluted and applicated dermally after warmed up in a waterbath.
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g - Duration of treatment / exposure:
- 24 hours
- Observation period:
- After 24 hours (directly after removing the patch) and after 72 hours. After 7 days, localizations were controlled finally.
- Number of animals:
- 5 animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm^2
- Type of wrap: Cellulose patch which was fixed by means of leucoplast. All the trunk of the animals was wrapped with a rubber cloth for 24 hours.
OBSERVATION TIME POINTS
24 hours, 72 hours and 7 days after start of treatment
SCORING SYSTEM:
- Method of calculation: According to Draize (1959, see "Any other information on materials and methods incl. tables). Substances with an index of primary irritation of 2 or less are no to mild stimulating substances, those with an index of 2 to 5 moderate ones and those with an index of 5 more are strong stimulants. - Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no skin irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no irritation observed
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation was only checked at 24 and 72 hours.
- Other effects:
- - Other adverse local effects: No
- Other adverse systemic effects: No - Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo skin irritation study in rabbits according to OECD guideline 404 and GLP, no skin irritation was observed under the conditions of the study.
- Executive summary:
The test compound was tested undiluted in a primary skin irritation test in rabbits according to OECD 404 and GLP. No irritation could be observed after 24 and 72 hours under the conditions of the study. The index of primary irritations (mean of 24- and 72-hour values) was 0, therefore the compound is considered to be non-irritant. After 7 days, the skin of the animals was checked again and no signs of irritation was observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-07-21 to 1986-07-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Albino rabbits
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young adult
- Weight at study initiation: 2.5-3.0 kg
- Housing: Individually in suspended, galvanized cages, fitted with wire-mesh floor and front
- Diet: Ad libitum
- Water: Ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 + 3
- Humidity (%): At least 40
- Air changes (per hr): Approx. 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From day 0 to day 3 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL of melted test substance, cooled down to 30°C - Duration of treatment / exposure:
- The eyes were not washed out following administration, thus animals were exposed to the test substance for the full observation period of 72 hours.
- Observation period (in vivo):
- 72 hours (effects were scored after 24, 48 and 72 hours)
- Number of animals or in vitro replicates:
- Three male animals were treated with a single concentration
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: No
SCORING SYSTEM: According to Draize (see "Any other information on materials and methods incl. tables") - Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo eye irritation study in rabbits according to OECD guideline 405, the test item was found to be non-irritating to the eyes.
- Executive summary:
In an eye irritation study according to OECD guideline 405 and GLP, the test item was examined undiluted for acute eye irritation/corrosion in three albino rabbits. Eye effects were examined after one hour, and after 24, 48 and 72 hours and scored according to the Draize scala. The test substance caused slight eye effects in all (three) rabbits 1 hour after treatment (slight redness and slight swelling of the conjunctivae) which was graded with a score of 1. After 24 hours, all eye effects had cleared completely (score of 0). The overall 24/48/72 hour score was 0 for corneal opacity, iris, and redness or chemosis of the conjunctivae. On the basis of the results obtained, it was concluded that the undiluted test substance is not an eye irritant and not corrosive to eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Key, Skin irritation in vivo, RL2
The test compound was tested undiluted in a primary skin irritation test in rabbits according to OECD 404 and GLP. No irritation could be observed after 24 and 72 hours under the conditions of the study. The index of primary irritations (mean of 24- and 72-hour values) was 0, therefore the compound is considered to be non-irritant. After 7 days, the skin of the animals was checked again and no signs of irritation were observed.
Key, Eye irritation in vivo, RL1
In an eye irritation study according to OECD guideline 405 and GLP, the test item was examined undiluted for acute eye irritation/corrosion in three albino rabbits. Eye effects were examined after one hour, and after 24, 48 and 72 hours and scored according to the Draize scala. The test substance caused slight eye effects in all (three) rabbits 1 hour after treatment (slight redness and slight swelling of the conjunctivae) which was graded with a score of 1. After 24 hours, all eye effects had cleared completely (score of 0). The overall 24/48/72 hour score was 0 for corneal opacity, iris, and redness or chemosis of the conjunctivae. On the basis of the results obtained, it was concluded that the undiluted test substance is not an eye irritant and not corrosive to eyes.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on available data, the test item is not classified and labelled for skin and eye irritation according to Regulation (EC) No 1272/2008 (CLP), as amended for the eighteenth time in Regulation (EU) 2022/692.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.