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EC number: 401-700-2 | CAS number: 3100-36-5 CYCLOHEXADECENON; CYCLOHEXADECENONE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-07-05 to 1999-07-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: Bioconcentration: Flow-through Fish Test"; Council Directive 67/548/EWG C.13
- Version / remarks:
- 1998
- GLP compliance:
- yes
- Radiolabelling:
- no
- Details on sampling:
- Analysis of test and control media as well as fishsamples at 5 h, 24 h, 48 h, 72 h, 96 h and 168 h after test start during the uptake phase were performed. After the beginning of the depuration phase (174 h) analysis was carried out in water and in fish samples at 192 h, 216 h, 240 h and 264 h.
- Vehicle:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: Bio International B.V. (Netherlands)
- Length at study initiation: 2.5-3.5 cm
- Feeding during test
- Food type: Tetra Min fish food, ground;
- Amount: 2 % of body weight per day
- Frequency: twice per day
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 174 h
- Total depuration duration:
- 89 h
- Hardness:
- 12.1 °dH
- Test temperature:
- Uptake phase:
control: 21.9-23.6 °C;
Test solution: 22.1-24.2 °C;
Depuration phase:
control: 21.6-23.8 °C;
Test solution: 22.5-23.7 °C - pH:
- Uptake phase:
control: 7.6-7.9;
Test solution: 7.6-7.8;
Depuration phase:
control: 7.8-8.1;
Test solution: 7.8-8.1 - Dissolved oxygen:
- Uptake phase:
control: 83.5-93.4% of saturation
Test solution: 86.3-96.8% of saturation
Depuration phase:
control: 93.1-103.6% of saturation
Test solution: 92.8-107.1% of saturation - Details on test conditions:
- TEST SYSTEM
- Test vessel (size):600 x 295 x 290 mm;
- Type: open
- Fill volume: 40 L
- Aeration: yes
- Type of flow-through: proportional diluter
- No. of organisms per vessel: 100
OTHER TEST CONDITIONS
- Photoperiod:16 hours light / 8 hours dark - Nominal and measured concentrations:
- Nominal concentration: 7.0 µg/L;
Measured concentration:
During the uptake phase in Test medium: 0.7-1.9 µg/L; During the uptake phase in Fish: 95-346 µg/kg;
During the depuration phase in Test medium: 0.7-1.9 µg/L; During the depuration phase in Fish: 98-35-15-13 µg/kg on day 1, 2, 3, 4. - Lipid content:
- 4.2 %
- Time point:
- start of exposure
- Lipid content:
- 6.1 %
- Time point:
- end of exposure
- Key result
- Conc. / dose:
- 7 µg/L
- Temp.:
- 23 °C
- pH:
- 7.7
- Type:
- BCF
- Value:
- 244 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Rate constant:
- overall depuration rate constant (d-1)
- Value:
- -0.035
- Rate constant:
- overall uptake rate constant (L kg-1 d-1)
- Remarks on result:
- not determinable
- Remarks:
- The rapid achievement of steady-state conditions during the uptake phase did not allow for a determination of the uptake rate constant (k1).
- Details on results:
- Not reported in details
- Validity criteria fulfilled:
- yes
- Conclusions:
- The bioconcentration factor (BCF) of the test item was determined to be 244 at steady state.
- Executive summary:
The study on the bioaccumulation potential was performed according to Council Directive 67/548/EWG C.13, "Bioconcentration: Flow-through Fish Test" (1998) and GLP. The test was carried out with Zebra fish under a flow through condition with a concentration level of 7 µg/L. The durations of uptake phase and depuration phase were 174 hours and 89 hours, respectively. The concentration of the test item was determined via GC/MS method. The bioconcentration factor (BCF) of the test item was determined to be 244 at steady state.
Reference
Description of key information
A study on the bioaccumulation potential is available, which was performed according to Council Directive 67/548/EWG C.13, "Bioconcentration: Flow-through Fish Test" (1998) and GLP. The test was carried out with Zebra fish under a flow through condition with a concentration level of 7 µg/L. The durations of uptake phase and depuration phase were 174 hours and 89 hours, respectively. The concentration of the test item was determined via GC/MS method. The bioconcentration factor (BCF) of the test item was determined to be 244 at steady state.
Key value for chemical safety assessment
- BCF (aquatic species):
- 244 dimensionless
Additional information
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