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EC number: 260-394-7 | CAS number: 56819-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Code number: FAT20010/C
Batch no: 149
Purity: ca. 70 %
Appearance: solid
Solubility: >1 g/I miscible [in water]
Storage: room temperature
Expiration date: 12/1999 - Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- Stock solution
110 mg test substance were mixed with 200 ml test medium in a beaker and then filled up to 500 ml with test medium. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Method of breeding: Cultures of Daphnia magna are held in glass vessels containing approx. 3.0 litre of reconstituted water at 18 - 22 °C. The water is renewed partially three times per week. The Daphnia are fed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a Tetramin-extract in such quantities that the food will be consumed within 24 hours
Pretreatment:
- 24 hours before the start of the exposure reproductive Daphnia were separated from the young Daphnia by sieving all individuals through a 1000 μm sieve.
For each test concentration 20 Daphnia divided in two groups of 10 animals were used. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 231 mg/L CaCO3
- Test temperature:
- 18-22 °C (during the test max. ± 1 °C),
- pH:
- 7.6 - 8.0
- Nominal and measured concentrations:
- Due to the results of a pretest the nominal test concentrations were chosen as 0.9, 1.9, 4.3, 9.4, 21, 45 and 100 mg test article/L. All test concentrations contained the vehicle Tween 80 (Polyoxyethylensorbitan-monooleat) in a concentration of 5 ppm. The test concentrations of 0.9, 1.9 and 4.3 mg/I were below the NOEC. Therefore, the data of these concentrations were not used for the determination of the EC values and were not presented in the report, but are documented in the raw data of the study.
- Details on test conditions:
- Experimental conditions
48 hours at nominal 18-22 °C (during the test max. ± 1°C), 12 hours light 12 hours dark. The Daphnia were exposed to the test substance in 250 ml beakers containing 80-100 ml test medium with 10 animals per beaker. All tests are running in duplicate. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 78 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No significant immobilization and abnormal behaviour of the Daphnia was observed in the controls. In the vehicle control one Daphnia was immobilized after 48 hours. This effect was inside the range of 10 % required by the guidelines for the validity of the test. In the test concentration of 7.9 mg/I (nominal 9.4 mg/I) no immobilization of the Daphnia occurred. Therefore, the NOEC and EC0 value after 48 hours was determined to be 7.9 mg/L.
- Results with reference substance (positive control):
- 48h EC50 = 0.93 mg/I.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 values after 48 hours was calculated as 31 mg/I.
- Executive summary:
A test was conducted to determing the acute fish toxicity of FAT 20010/C to Daphnia magna was carried out to determine the EC50 (concentration at which 50 % of the Daphnia population is immobilized) according to OECD guideline 202 in compliance with GLP. 10 Daphnids each were exposed to concentration of 9.4, 21, 45 and 100 mg/L. During the test the actual test concentrations in the analysed test media were in the range of 77.6 - 85.1 % of the nominal values. No significant immobilization and abnormal behaviour of the daphnids was observed in the controls. In the test concentration of 7.9 mg/I (nominal 9.4 mg/I) no immobilization of the daphnids occurred. Therefore, the NOEC and EC0 value after 48 hours was determined to be 7.9 mg/I. The EC50 values after 48 hours was calculated to be 31 mg/L.
Reference
Description of key information
48 h EC50 value of FAT 20010/C to Daphnia magna was calculated to be 31 mg/L. The NOEC and EC0 value after 48 hours was determined to be 7.9 mg/I.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 31 mg/L
Additional information
A GLP-compliant test was performed to assess the toxicity of test substance FAT 20010/C to Daphnia magna according to OECD guideline 202. At the end of 48 h exposure period the EC50 value of FAT 20010/C to Daphnia magna was calculated to be 31 mg/L. The NOEC and EC0 value after 48 hours was determined to be 7.9 mg/I.
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