Registration Dossier
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EC number: 260-394-7 | CAS number: 56819-40-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification: FAT 20010/E TE Lot. 59015
Appearance: Red powder - Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 0.982
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not known
- Type:
- log Pow
- Partition coefficient:
- -0.008
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not known
- Conclusions:
- The partition coefficient n-octanol/water of the test item at 20 °C was determined to be:
Pow = 0.982
Log Pow = -0.008 - Executive summary:
The purpose of the study was determination of the partition coefficient n-octanol / water of the test item FAT 20010/E according to the European Commission Regulation (EC) No.440/2008, A.8. partition coefficient n-octanol / water and OECD 107 and OECD 117, partition coefficient n-octanol/water. The shake flask method was used for this purpose. Based on the findings of the study, the partition coefficient n-octanol/water of the test item at 20 °C was determined to be:
Pow = 0.982
Log Pow = - 0.008
Reference
Preliminary Visual Estimation of the n-octanol solubility
Amount of test item in mg |
Volume in ml |
Total volume in ml |
Stirring time |
Appearance of mixture |
100 |
10 |
10 |
60 min |
Undissolved |
|
25 |
25 |
60 min |
Dissolved |
|
50 |
50 |
60 min |
Dissolved |
Determination of the solubility in the n-Octanol phase: Flask Method
Experiment |
A |
B |
C |
D(blank) |
Amount of test item (mg) |
1000 |
1000 |
1000 |
-- |
Stirring time at 30°C (h) |
24 |
48 |
72 |
72 |
Aliquot of the flasks (ml) |
0.05 |
0.05 |
0.05 |
0.05 |
End volume (ml) |
10 |
10 |
10 |
10 |
Measured concentration (µg/ml) |
22.2 |
21.6 |
22.0 |
-- |
Solubility(g/l) |
4.5 |
4.3 |
4.4 |
-- |
Description of key information
The partition coefficient n-octanol/water of the test item at 20 °C was determined to be:
Pow = 0.982
Log Pow = -0.008
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.008
- at the temperature of:
- 20 °C
Additional information
The purpose of the study was determination of the partition coefficient n-octanol / water of the test item FAT 20010/E according to the European Commission Regulation (EC) No.440/2008, A.8. partition coefficient n-octanol / water and OECD 107 and OECD 117, partition coefficient n-octanol/water. The shake flask method was used for this purpose.
Based on the findings of the study, the partition coefficient n-octanol/water of the test item at 20 °C was determined to be:
Pow = 0.982
Log Pow = - 0.008
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