Registration Dossier
Registration Dossier
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EC number: 600-735-2 | CAS number: 106276-79-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is not bioaccumulative.
Key value for chemical safety assessment
Additional information
According to the logPow the test substance is regarded as not bioaccumulative (logPow => 0.46).
Additionally, the comparison of the low octanol solubility compared to the critical body burden (CBB) is an indicator for the low bioaccumulation potential of the test substance. If the solubility of a substance in octanol is so low that the maximum concentration levels that can be attained in organisms do not reach levels sufficient to elicit any toxic effects, it can be reasoned that such accumulation would not be of concern. The concentration of a substance at which the occurrence of toxic effects normally can be excluded is 0.002 mmol/l in n-octanol. As octanol is a reasonable surrogate for fish lipid, a low substance concentration in octanol may indicate reduced bioconcentration / bioaccumulation potential. The concept is based on available measurements for substances with narcotic mode of action using a safety factor of 10 for the uncertainty of the available CBB measurements. It is proposed that where a chemical shows no specific mode of action and has a Coctanol [mg/L] < 0.002 [mMol/L] x Mol weight [g/Mol] it can be assumed that the compound has only a limited potential to establish high body burdens and to bioaccumulate. If it does bioaccumulate, it would be unlikely to rise to levels in biota that would cause significant effects.
Therefore, if the octanol solubility is below the CBB, the maximum uptake of the substance can be expected to be below the CBB and toxicity is not likely.
For the test substance the solubility in octanol was measured to be 0.092 mg/L and is well below the estimated CBB of 1.2942 mg/L - 1.312 mg/L. Furthermore, the pigment is practically insoluble in water and therefore considered to be essentially not bioavailable. Due to the large molecular size of 647.1 - 656 g/Mol cellular uptake of the pigment is unlikely.
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