Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
EC# 457-320-2 showed no evidence of mutagenic potential in an Ames test, and EC# 434-650-5 - a substance structurally and chemically similar to EC# 457-320-2 - showed no evidence of genotoxic potential in an in vitro chromosome aberraton study and an in vivo mouse micronucleus study. In view of the similarity of the two substances, it is concluded that further testing on EC# 457-320-2 is unnecessary and read-across to the results for EC# 434-650-5 can be justifiably used. It is therefore concluded that EC# 457-320-2 is not genotoxic.
Short description of key information:
EC# 457-320-2 showed no evidence of mutagenic potential in an Ames test, and a substance structurally and chemically similar to EC# 457-320-2 showed no evidence of genotoxic potential in an in vitro chromosome aberraton study and an in vivo mouse micronucleus study.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
EC# 457-320-2 showed no evidence of mutagenic potential in an Ames test, and EC# 434-650-5 - a substance structurally and chemically similar to EC# 457-320-2 - showed no evidence of genotoxic potential in an in vitro chromosome aberraton study and an in vivo mouse micronucleus study. In view of the similarity of the two substances, it is concluded that further testing on EC# 457-320-2 is unnecessary and read-across to the results for EC# 434-650-5 can be justifiably used. It is therefore concluded that EC# 457-320-2 is not genotoxic. Consequently, in accordance with the CLP Regulation in the absence of specific germ cell mutagenicity data, no classification is proposed for germ cell mutagenicity.
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