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EC number: 457-320-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
In an algal growth inhibition study of EC# 434-650-5, the 72-hour NOELR based on cell number was 4.05 mg/litre (nominal loading rate).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 9.62 mg/L
- EC10 or NOEC for freshwater algae:
- 4.05 mg/L
Additional information
No toxicity to aquatic algae and cyanobacteria studies are available for EC# 457-320-2; however, one study is available for the structurally and chemically similar substance EC# 434-650-5: a 72-hour algal growth inhibiton study conducted to GLP and in accordance with OECD Test Guideline 201. Due to the poor solubility of the test material (which was 87% pure EC# 434-650-5) in solvents that would not affect algal growth, test waters were prepared as Water Accomodated Fractions (WAFs) of nominal loading rates of active ingredient (i.e. EC# 434-650-5). WAFs were sampled and analysed for molybdenum (Mo) content, and the concentrations of EC# 434-650-5 calculated.
Nominal loading rates were 0, 4.05, 8.89, 19.7, 43.1 and 94.6 mg a.i./litre. Based on the measured levels of Mo at 0 and 72 h (0.0124, 0.0451, 0.0547, 0.127 and 0.517 mg Mo/litre), the actual concentrations of active ingredient were calculated to be 0.135, 0.492, 0.597, 1.38 and 5.64 mg/litre; however, since the Mo content of the water-soluble portion of the test material is not known, these values should be treated with caution.
The test material caused a concentration-related inhibition of algal growth. The no-observed-effect loading rate was 4.05 mg a.i./litre, based on cell number, and the EbL50 and EtL50 were 9.62 and 14.0 mg a.i./litre, respectively, based on area under the growth curve and average specific growth rate.
In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.
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