Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Testing was not carried out according to Method C7 of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:
The test material was experimentally determined to have a very low water solubility value of <1.00 x 10-6g/l (1 µg/L or 1 ppb) The guideline states in (b)(5) Applicability and Specificity “For chemicals whose solubility is below 1 ppb, the water solubility should be characterized as ‘less than 1 ppb’ with no further quantification.”
The hydrolysis guidelines require an initial solution concentration of less than one-half the water solubility for materials determined to have a water solubility of less than 2 x 10-2M. This requirement conflicts with the above outlined reporting limit imposed by the water solubility guideline that was applicable to this test substance. Additionally, the guidelines also require use of an analytical method capable of determining solution concentrations of the test material at 10% of the initial test concentration, further increasing the sensitivity that an analytical method would require. For this material, test material concentrations, even after extracting and concentrating the samples, would likely to be less than the limit of quantification.
Key value for chemical safety assessment
Additional information
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