Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since the reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- publication
- Title:
- Synergistic toxicity and carcinogenicity of "Freons" and piperonyl butoxide
- Author:
- Epstein SS et al.
- Year:
- 1 967
- Bibliographic source:
- Nature 214:526-528 (1967)
Materials and methods
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- IUPAC Name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 8 weeks, prior to mating
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
200 mg/kg bw
Basis:
- Remarks:
- Doses / Concentrations:
1000 mg/kg bw
Basis:
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
No increase in dominant lethal was seen in female rats. - Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose data deriving from scientific literature were rewieved.
The result of a dominant lethal assay is reported. Under the study, females rats were treated with intraperitoneal injections of either 200 or 1000 mg/kg for eight weeks before mating with untreated male rats.
No increase in dominant lethal was seen.
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