Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Reference Type:
- publication
- Title:
- Fully Halogenated Chlorofluorocarbons
- Author:
- World Health Organization (WHO)
- Year:
- 1 990
- Bibliographic source:
- In: Environmental Health Criteria 113, p 60. WHO, Geneva
- Reference Type:
- review article or handbook
- Title:
- Environmental and Occupational medicine.
- Author:
- Rom WN (Ed)
- Year:
- 1 992
- Bibliographic source:
- Environmental and Occupational medicine. 2nd edition, p 1299. Little Brown and Company, Boston, MA
Materials and methods
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- IUPAC Name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Absorption, distribution, metabolism and excretion of 1,1,2,2 -tetrachloro-1,2 –difluoroethane are discussed under the ACGIH sheet for the substance.
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection, and to this purpose the available scientific data on substances are revised.
According to the reference, chlorofluorocarbons as 1,1,2,2 -tetrachloro-1,2 –difluoroethane, appear to be eliminated almost exclusively through the respiratory tract. Little, if any, chlorofluorocarbon or metabolite has ever been reported in urine and feces. 1,1,2,2 -tetrachloro-1,2 –difluoroethane is absorbed by the lung and undergoes little, if any, significant biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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