Tetrachloro-1,2-difluoroethane

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: discussion based on literature data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The source is considered reliable since the reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE

Author:

American Conference of Industrial Hygienists (ACGIH)

Year:

2008

Bibliographic source:

1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication

Reference 2

Reference Type:

review article or handbook

Title:

Toxicology, 2nd ed.

Author:

Hardman et al.

Year:

1963

Bibliographic source:

Toxicology, 2nd ed., p1330. Interscience publishers, New York (1963)

Materials and methods

Study type:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

IUPAC Name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

Constituent 2

Reference substance name:

Tetrachloro-1,2-difluoroethane

EC Number:

200-935-6

EC Name:

Tetrachloro-1,2-difluoroethane

Cas Number:

76-12-0

Molecular formula:

C2Cl4F2

IUPAC Name:

1,1,2,2-tetrachloro-1,2-difluoroethane

Test material form:

not specified

Details on test material:

Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Method

Route of exposure:

inhalation

Reason of exposure:

other: accidental and/or unintentional

Results and discussion

Any other information on results incl. tables

Prolonged exposure of daily use may result in damage to several organ system. Clinical problems include cardiac arrhythmias, bone marrow depression, cerebral degeneration, and damage to liver, kidney, and peripheral nerves.

Death occasionally has been attributed to inhalant abuse, probably via the mechanism of cardiac arrhytmias, especially accompanying exercise or upper airway obstruction.

Applicant's summary and conclusion

Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose, the scientific literature on substances are revised.

According to the quoted reference, aerosol sprays containing fluorocarbon propellants including 1,1,2,2 -tetrachloro-1,2 -difluoroethane were a source of solvent intoxication in the past. Prolonged exposure of daily use may result in damage to several organ system. Clinical problems include cardiac arrhythmias, bone marrow depression, cerebral degeneration, and damage to liver, kidney, and peripheral nerves.

Death occasionally has been attributed to inhalant abuse, probably via the mechanism of cardiac arrhytmias, especially accompanying exercise or upper airway obstruction.

As already discussed under section 7.5 "Repeated dose toxicity", 1,1,2,2,-tetrachloro - 1,2 -difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure according to Regulation (EC) No. 1272/2008.