Tetrachloro-1,2-difluoroethane

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation

Remarks:

no data

Type of information:

other: discussion based on literature data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE

Author:

American Conference of Industrial Hygienists (ACGIH)

Year:

2008

Bibliographic source:

1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1966

Materials and methods

Principles of method if other than guideline:

not reported

GLP compliance:

not specified

Type of study:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

IUPAC Name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

Constituent 2

Reference substance name:

Tetrachloro-1,2-difluoroethane

EC Number:

200-935-6

EC Name:

Tetrachloro-1,2-difluoroethane

Cas Number:

76-12-0

Molecular formula:

C2Cl4F2

IUPAC Name:

1,1,2,2-tetrachloro-1,2-difluoroethane

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

In vivo test system

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Results and discussion

Any other information on results incl. tables

Mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs, no evidence of sensitisazion was seen. (Clayton et al, 1966).

Applicant's summary and conclusion

Interpretation of results:

not sensitising

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for skin sentitisation.

Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose,data deriving from scientific literature were rewieved.

ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondaty source of information.

The result of a skin sensitisation study is reported. Under the study, 1,1,2,2 -tetrachloro-1,2 -difluoroethane was applied dermally to the skin of guinea pings. According to the reference, no evidence of sensitisazion was seen. (Clayton et al, 1966).