Registration Dossier
Registration Dossier
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EC number: 939-600-0 | CAS number: 1471316-27-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation
The potential of skin sensitisation of Alcohols, C16-18 (even numbered) and C18 unsaturated, propoxylated, <2.5 PO (CAS 70955-07-6) was investigated in a Buehler test conducted according to OECD Guideline 406 under GLP conditions (Richeux, 2012).
Induction of 20 guinea pigs was performed by 3 topical applications at Day 0, 6 and 14 with undiluted test substance. After 14-days the challenge phase, under occlusive dressing for 6 h, consisted of a single topical application of the test item at 10%.
The sensibility of the test is confirmed by regular tests with a positive control (Reference substance: α-Hexylcinnamaldehyde CAS n° 101-86-0 - Tests n°11-13).
24 and 48 h after patch removal the application site was assessed for sings of local irritation. No dermal reactions were observed in any test animal at any time point.
Migrated from Short description of key information:
Buehler Test (OECD 406): not sensitising
Justification for selection of skin sensitisation endpoint:
Reliable OECD Guideline study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
No data available.
Justification for classification or non-classification
According to the classification criteria of Directive 67/548/EEC and Regulation (EC) No 1272/2008 the substance does not need to be classified for skin sensitization. No data is available for respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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