Registration Dossier
Registration Dossier
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EC number: 939-600-0 | CAS number: 1471316-27-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary of toxicological information. Therefore only limited data are available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Only 3 instead of 5 animals of one sex. Occlusive instead of semi-occlusive conditions. Only limited data on methodology and results available.
- Principles of method if other than guideline:
- The back and flanks of 6 male and 6 female New Zealand Albino rabbits were clipped. The test sites of 3 males and 3 females were abraded. 5000 mg/kg bw were applied to the skin under occlusive conditions for 24 h. After removal of the patch skin reactions were scored according to Draize, J.H. et al., 1944 and the skin was washed subsequently. Animals were observed for clinical signs of toxicity for 14 days.
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 25231-21-4
- EC Number:
- 607-655-7
- Cas Number:
- 25231-21-4
- IUPAC Name:
- 25231-21-4
- Test material form:
- not specified
- Details on test material:
- - Test material: alcohol C18, 15PO
- Analytical purity: not reported
- Peroxylation grafe: 15
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 3 (intact skin), 3 (abraded skin)
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Minimal soft feces were observed until day 9 at various times. No further signs of toxicity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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