Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-254-4
CAS number: 932-64-9
Review of the data collected for each guinea pig in the treatment group
indicates that all challenge injections were within the limits of the
reactions recorded during the sensitizing period. The guinea pig skin
sensitization study did not show the test substance to be a sensitizer.
An intradermal guinea pig assay on NTO was carried out (London and
Smith, 1985). Ten female guinea pigs were treated with concentrations of
0.1% NTO in corn oil. The compound was administered in a series of ten
sensitizing injections into the lower back and flanks of the guinea
pigs. Injections were made randomly over the test area. Twenty four
hours after injection the reaction was scored for erythema and swelling.
Two weeks after administration of the tenth sensitizing injection, the
lower back and flanks of each guinea pig were clipped free of hair and a
challenge injection of 0.05 mL was administered. The reaction of each
animal was graded 24 hr later and compared with those from the
sensitising injections. All challenge injections were within the limits
of the reactions recorded during the sensitizing period. Therefore NTO
was not shown to be a skin sensitizer.
Migrated from Short description of key information:
The guinea pig skin sensitisation study did not show NTO to be a skin sensitiser.
Justification for selection of skin sensitisation endpoint:
The study was run to a detailed, scientific method though not to GLP.
NTO is not classified as a skin sensitizer as the skin sensitization
study provided a negative result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again