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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study run to a detailed method. None GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Twenty-five young adult (≈ 68 days) Sprague-Dawley male rats were used in the 5 g/kg test group. After the treatment, all animals were observed daily for 30 days for aberrant physiological and behavioral responses.
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material : 3-NITRO-1 ,2,4-TRIAZOL-5-0NE (NTO)
- Substance type: energetic explosive
- Physical state: light green to white crystalline solid with no odor
- Purity ca.99%
Specific details on test material used for the study:
Batch No.: not specified
Purity: not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Age at study initiation: ≈ 68 days
- Weight at study initiation: 290-330 g

No additonal data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 500 mg/cc of corn oil
- Justification for choice of vehicle: This vehicle was used to solubilize the mixture in an innocuous medium.

No additional data
Doses:
5 g/kg
No. of animals per sex per dose:
25 male rats per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 30 days
- Frequency of observations and weighing: After treatment , all animals were observed daily for 30 days for aberrant physiological and behavioral responses.

No additional data
Statistics:
None stated

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality
Clinical signs:
In general, all rat behavioral, clinical, and physiological responses after administration appeared normal.
Body weight:
No information provided
Gross pathology:
No information provided
Other findings:
No information provided

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 value for NTO to Sprague-Dawley rat was greater than 5 g/kg.