N-octylpyridin-4-amine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental starting date: 09 April 2018, Experimental completion date: 12 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

N-octylpyridin-4-amine

EC Number:

265-019-0

EC Name:

N-octylpyridin-4-amine

Cas Number:

64690-19-3

Molecular formula:

C13H22N2

IUPAC Name:

N-octylpyridin-4-amine

Results and discussion

Water solubility

Key result

Water solubility:

12.8 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

9.4

Any other information on results incl. tables

Preliminary Test

The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 2.07 x 10-2 g/L. The solution had a pH of 9.4.

 

Definitive Test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Table 2

Solution	Mean Peak Area
Standard 20.3 mg/L	5.4075 x 106
Standard 21.1 mg/L	5.2875 x 106
Matrix blank	none detected
Sample 1A	1.7585 x 106
Sample 1B	1.7779 x 106
Sample 2A	1.6656 x 106
Sample 2B	1.6478 x 106
Sample 3A	1.5385 x 106
Sample 3B	1.5618 x 106

 

The concentration (g/L) of test item in the sample solutions is shown in the following table:

Table 3

Sample Number	Time Shaken at ~ 30 ºC (hours)	Concentration (g/L)	Solution pH
1	24	1.37 x 10-2	9.5
2	48	1.28 x 10-2	9.5
3	72	1.20 x 10-2	9.6

 

Overall concentration : 1.28 x 10-2 g/L at 20.0 ± 0.5 ºC

 

 

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5 to 50 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.

Discussion

On completion of the equilibration period, the samples were clear and colourless with excess test item present. After filtration, the filtrates were visually observed to be clear, colourless and free from un-dissolved test item. The filtrates did exhibit a Tyndall beam effect.

 

Applicant's summary and conclusion

Conclusions:

The water solubility of the test item has been determined to be 1.28 x 10-2 g/L of solution at 20.0 ± 0.5 °C.