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EC number: 265-019-0 | CAS number: 64690-19-3
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 09 April 2018, Experimental completion date: 12 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- N-octylpyridin-4-amine
- EC Number:
- 265-019-0
- EC Name:
- N-octylpyridin-4-amine
- Cas Number:
- 64690-19-3
- Molecular formula:
- C13H22N2
- IUPAC Name:
- N-octylpyridin-4-amine
Constituent 1
Results and discussion
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 12.2 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 0.182 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.011 %
Any other information on results incl. tables
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Table 2
Measurement |
Result |
Mass of test item transferred to sieve (W1) |
16.05 g |
Mass of test item passed through sieve (W3– W2) |
1.96 g |
Percentage of test item less than 100 µm |
12.2% |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Table 3
Collection Stage |
Particle Size Range Collected (µm) |
Collected Mass (g) |
||
Determination 1 |
Determination 2 |
Determination 3 |
||
Artificial throat |
n/a |
0.09 |
0.19 |
0.04 |
Sample Cup 1 |
>10.0 |
2.9314 |
2.7018 |
2.9365 |
Sample Cup 2 |
5.5 to 10.0 |
0.0038 |
0.0082 |
0.0031 |
Sample Cup 3 |
2.4 to 5.5 |
0.0000 |
0.0000 |
0.0002 |
Sample Cup 4 |
1.61 to 2.4 |
0.0001 |
0.0001 |
0.0000 |
Sample Cup 5 |
0.307 to 1.61 |
0.0000 |
0.0002 |
0.0000 |
Final Filter |
<0.307 |
0.0002 |
0.0001 |
0.0001 |
Total mass of collected test item |
3.0255 |
2.9004 |
2.9799 |
|
Mass of test item added |
3.0491 |
2.9916 |
3.0374 |
|
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Table 4
Particle Size Cut Points (µm) |
Cumulative Mass (g) |
Cumulative Percentage (%) |
||||
Determination 1 |
Determination 2 |
Determination 3 |
Determination 1 |
Determination 2 |
Determination 3 |
|
<10.0 |
0.0041 |
0.0086 |
0.034 |
0.136 |
0.297 |
0.114 |
<5.5 |
0.0003 |
0.0004 |
0.0003 |
0.010 |
0.014 |
0.010 |
<2.4 |
0.0003 |
0.0004 |
0.0001 |
0.010 |
0.014 |
0.003 |
<1.61 |
0.0002 |
0.0003 |
0.0001 |
0.007 |
0.010 |
0.003 |
<0.307 |
0.0002 |
0.0001 |
0.0001 |
0.007 |
0.003 |
0.003 |
Mean cumulative percentage with a particle size less than
10.0 µm : 0.182%
Mean cumulative percentage with a particle size less than
5.5 µm : 0.011%
Discussion
Sampling for the cascade impactor determinations was performed bytaking the samples from different areas of the test item.
Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Conclusion
Particle size data acquired for the test item is shown in the following table:
Table 5
Measurement |
Method |
Result |
Percentage of test item with an inhalable particle size <100 µm |
Sieve |
12.2% |
Percentage of test item with a thoracic particle size <10.0 µm |
Cascade Impactor |
0.182% |
Percentage of test item with a respirable particle size <5.5 µm |
Cascade Impactor |
0.011% |
Applicant's summary and conclusion
- Conclusions:
- Percentage of test item with an inhalable particle size <100 µm = 12.2%
Percentage of test item with a thoracic particle size <10.0 µm = 0.182%
Percentage of test item with a respirable particle size <5.5 µm = 0.011%
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