Registration Dossier
Registration Dossier
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EC number: 246-309-6 | CAS number: 24549-06-2
Endpoint summary
Administrative data
Description of key information
According to the findings of the subacute oral toxicity study a LOAEL of 221 mg/kg body weight can be determined, but with the restriction that the study has limitations concerning dosage and observation parameters compared to the guideline study. No classification is required according to the available data base.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 221 mg/kg bw/day
Additional information
Repeated dose toxicity: oral
In a subacute toxicity study male Fischer 344 rats were treated orally via gavage needle with 2-methyl-6-ethylaniline (221 mg/kg and day). The rats were treated for 5, 10 or 20 days. No clinical signs and mortality were seen in the 2-methyl-6-ethylaniline (MEA) treated rats. The body weight of the treated rats was not significant different to the concurrent control rats. No significant differences in organ weights of liver, kidney and spleen were found in the treated rats compared to the control group. In addition no histopathological lesions were found in the liver, esophagus, trachea, thyroid, para-thyroid, urinary bladder, and spleen after MEA treatment, whereas a hypercellularity in the bone marrow was seen after MEA treatment. The effect was significant different from control on day 10, but not on day 20 (Short 1983). According to the findings of this study a LOAEL of 221 mg/kg body weight can be determined, but with the restriction that the study has limitations concerning dosage and observation parameters compared to the guideline study. No classification is required according to the available data base.
Repeated dose: dermal
There are no data available for the dermal repeated dose toxicity.
Repeated dose: inhalation
There are no data available for the inhalation repeated dose toxicity.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: bone marrow
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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