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EC number: 425-200-9 | CAS number: 188570-78-7
Toxicity was observed towards all the tester strains at 5000 and 1500 µg/plate.
In the in vitro assessment of the mutagenic potential of Montaverdi, histidine dependent auxotrophic mutants of Salmonella typhimurium (strains TA1535, TA1537, TA98 and TA100) and a tryptophan dependent mutant of Escherichia coli (strain CM891) were exposed to the test substance diluted in dimethyl sulphoxide (DMSO), which was also used as a negative control. Two independent mutation tests were performed in the presence and absence of liver preparations from Aroclor 1254-induced rats (S9 mix). The first was a standard plate incorporation assay, the second involved a pre-incubation stage. Dose levels of up to 5000 µg/plate were tested in the first mutation test. This is the standard limit dose recommended in the regulatory guidelines this assay follows. Other dose levels used were a series of ca half-Iog1o dilutions of the highest concentration. Toxicity was observed towards all the tester strains at 5000 and 1500 µg/plate in the first mutation test, therefore a top dose level of 1500 µg/plate was chosen for the second mutation test. Toxicity was observed towards all the tester strains at 1500 and 500 µg/plate in the second mutation test. No evidence of mutagenic activity was seen at any dose level of Montaverdi in either mutation test.
The concurrent positive control compounds demonstrated the sensitivity of the assay and the metabolizing activity of the liver preparations.
It is concluded that, when tested in DMSO, Montaverdi shows no evidence of mutagenic activity in this bacterial system.
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