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EC number: 425-200-9 | CAS number: 188570-78-7
Table 1 Dermal reactions
Rabbit no. & sex
E = Erythema
O = Oedema
* Approximately 60 minutes after removal of the dressing
a Desquamation of the stratum corneum (Characterised by dryness and sloughing)
A study was performed to assess the skin irritation potential of Montaverdi to the rabbit. The method followed was that described in:
EEC Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation) and OECD Guideline for Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion". Adopted: 17 July 1992. Three rabbits were each administered a single dermal dose of 0. 5 ml of the test substance and observed for up to 14 days. A single semi-occlusive application of Montaverdi to intact rabbit skin for four hours elicited persistent welldefined dermal irritation. Reactions had resolved in one animal by Day 10 but slight erythema was noted in the remaining two rabbits at study termination on Day 14. The effects seen in 2 of the animals for the 14 day observation period were only minimal in nature and therefore classification as a category 2 irritant is not warranted.
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