Registration Dossier
Registration Dossier
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EC number: 473-450-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In an LLNA study in mice, a stimulation index of greater than 3 was recorded for the three concentrations of the test material (10%, 25% and 50%). No signs of systemic toxicity were observed in test or control animals during the study period. Very dark re-coloured staining of the fur was noted in test animals one hour post dosing throughout the study period. Based on the results of this study, the test substance is considered a skin sensitizer.
Migrated from Short description of key information:
An LLNA study in mice with the test substance is available. The test was performed according to OECD guidelines and GLP.
Justification for classification or non-classification
Based on the above mentioned result, the substance shall be classified for skin sensitization:
- according to the CLP Regulation (EC) 1272/2008: Skin Sens. 1, H317
- and according to the Dangerous Substance Directive 67/548/EC: Xi, R43
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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