Registration Dossier
Registration Dossier
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EC number: 473-450-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
The values for the acute toxicity to daphnia and the toxicity to algae were derived from studies performed according to OECD guidelines
and GLP principles.
After exposure to daphnia magna for 48 hours in a static test, an EC50 value of 14 mg/L (based on initial meeasured concentration) for isoindole derivative was found. Regarding toxicity to aquatic algae, the EC50 for growth rate reduction (0 -72 hr) based on TWA concentrations was 0.16 mg/L. The NOEC for growth rate reduction equalled a TWA concentration of 0.01 mg/L. Based on the algae results, in combination with the substances inability to rapidly degrade, the substance must be considered as hazardous to the aquatic environment and shall be classified according to CLP (EC) 1272/2008 as 'Category Acute 1' (H400: Very toxic to aquatic life) and 'Category Chronic 1' (H410: very toxic to aquatic life with long lasting effects). According to section 4.1.3 of the Guidance on the Application of Regulation (EC) No 1272/2008, the two Hazard statements are combined into H410.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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