Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The values for the acute toxicity to daphnia and the toxicity to algae were derived from studies performed according to OECD guidelines

and GLP principles.

After exposure to daphnia magna for 48 hours in a static test, an EC50 value of 14 mg/L (based on initial meeasured concentration) for isoindole derivative was found. Regarding toxicity to aquatic algae, the EC50 for growth rate reduction (0 -72 hr) based on TWA concentrations was 0.16 mg/L. The NOEC for growth rate reduction equalled a TWA concentration of 0.01 mg/L. Based on the algae results, in combination with the substances inability to rapidly degrade, the substance must be considered as hazardous to the aquatic environment and shall be classified according to CLP (EC) 1272/2008 as 'Category Acute 1' (H400: Very toxic to aquatic life) and 'Category Chronic 1' (H410: very toxic to aquatic life with long lasting effects). According to section 4.1.3 of the Guidance on the Application of Regulation (EC) No 1272/2008, the two Hazard statements are combined into H410.