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EC number: 700-840-4 | CAS number: 160583-22-2
A study on repeated toxicity is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasable. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.
Stability testing demonstrated that 2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes immediately on contact with moisture, so polymerization will occur during administration. Due to this high reactivity the determination of a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not bioavailable after administration.
Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate on repeated dose toxicity is waived.
No sub-acute or chronic toxicity is expected since bioavailability of 2 -phenylethyl cyanoacrylate is unlikely due to its high reactivity.
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