Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Additional information

Stability testing demonstrated that 2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes immediately on contact with moisture, so polymerization will occur during oral administration. Due to this high reactivity the determination of a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not bioavailable after administration and any effect would originate from the resulting polymer or degradation products thereof.

 

Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate on developmental toxicity is waived.

 


Short description of key information:
A study on toxicity to reproduction is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasible. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.

Effects on developmental toxicity

Description of key information
A study on developmental toxicity is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasable. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Additional information

Stability testing demonstrated that 2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes immediately on contact with moisture, so polymerization will occur during oral administration. Due to this high reactivity the determination of a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not bioavailabe after administration and any effect would originate from the resulting polymer or degradation products thereof.

 

Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate on developmental toxicity is waived.

 

Justification for classification or non-classification

No developmental toxicity or toxicity to reproduction is expected as bioavailability of 2 -phenylethyl cyanoacrylate is unlikely due to its high reactivity.

Additional information