Registration Dossier
Registration Dossier
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EC number: 700-840-4 | CAS number: 160583-22-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Additional information
Stability testing demonstrated that 2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes immediately on contact with moisture, so polymerization will occur during oral administration. Due to this high reactivity the determination of a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not bioavailable after administration and any effect would originate from the resulting polymer or degradation products thereof.
Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate on developmental toxicity is waived.
Short description of key information:
A study on toxicity to reproduction is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasible. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.
Effects on developmental toxicity
Description of key information
A study on developmental toxicity is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasable. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Additional information
Stability testing demonstrated that 2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes immediately on contact with moisture, so polymerization will occur during oral administration. Due to this high reactivity the determination of a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not bioavailabe after administration and any effect would originate from the resulting polymer or degradation products thereof.
Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate on developmental toxicity is waived.
Justification for classification or non-classification
No developmental toxicity or toxicity to reproduction is expected as bioavailability of 2 -phenylethyl cyanoacrylate is unlikely due to its high reactivity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
