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EC number: 939-601-6 | CAS number: -
A series of studies were conducted to evaluate the teratogenic effects of a C16-C30 light mineral oil in pregnant Sprague-Dawley rats by three separate routes of exposure; inhalation (1000 mg/m3), dermal (2000 mg/kg bw/day), oral gavage (5000 mg/kg bw/day) with exposures on gestation days 6-19. Due to low vapor pressure, the mineral oil was delivered as an aerosol for the inhalation study though aerosol particle size generated was well within the respirable range. There were no observable maternal effects (food consumption, body weight gain) irrespective of route of exposure. No adverse effects on reproductive parameters (implantation number, resorptions, fetal viability) or fetal parameters (body weight, crown-rump length) were observed in any of the studies. There was a clear lack of teratogenicity with regard to abnormal ossification, and adverse effects to external or soft tissue. Spontaneous anomalies were noted in some exposure groups but were not considered exposure related since incidence of such occurrences were similar in the sham-exposed groups. NOAEL for developmental toxicity was ≥ 2000 mg/kg bw/day (dermal), 1000 mg/m3 (inhalation) and 5000 mg/kg bw/day (oral gavage).
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