Registration Dossier
Registration Dossier
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EC number: 938-445-6 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- analogue approach for alkylethersulfates contained in registered substance - see attached read across justification.
Data source
Reference
- Reference Type:
- publication
- Title:
- Environmental and human safety of major surfactants.
- Author:
- Arthur D. Little, Inc.
- Year:
- 1 991
- Bibliographic source:
- Volume 1. Anionic surfactants. Part 2. Alcohol ethoxy sulfates. Final report to: The Soap and Detergent Association
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 452 (Chronic Toxicity Studies)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Poly(oxy-1,2-ethanediyl),a-sulfo-w-(dodecyloxy)-, sodium salt
- IUPAC Name:
- Poly(oxy-1,2-ethanediyl),a-sulfo-w-(dodecyloxy)-, sodium salt
- Reference substance name:
- 98112-64-2
- EC Number:
- 619-320-2
- Cas Number:
- 98112-64-2
- IUPAC Name:
- 98112-64-2
- Test material form:
- not specified
- Details on test material:
- - Poly(oxy-1,2-ethanediyl), a-sulfo-w-(dodecyloxy)-, sodium salt
- Ethoxylation degree: 3EO
- Purity: No data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: Drinking water study & Feeding study
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
Examinations
- Observations and examinations performed and frequency:
- survival, growth, food consumption, body weights, clinical laboratory findings, hamatology and urinalyses.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- A slight, but consistently higher water consumption by all rats receiving the test compound in their drinking water and a significant
difference in the empty cecum to body weight ratio of females was oberved. - Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- > 250 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Feeding study
- Dose descriptor:
- NOAEL
- Effect level:
- > 75 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Drinking water study
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Executive summary:
Poly(oxy-1,2-ethanediyl),a-sulfo-w-(dodecyloxy)-, sodium salt was tested in a chronic toxicity feeding and drinking water study comparable to a OECD 452 guideline study on rats. A NOAEL of 250 mg/kg bw/day (nominal, feeding) was reported.
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