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EC number: 938-445-6
CAS number: -
In the Klimisch 1 GLP test the toxicity on activated sludge
microorganisms (Respiration Inhibition Test) according to OECD 209 and
EU method C.11. was determined. A range-finding test was performed in a
limit test design with the concentrations: 10, 100 and 1000 mg/L. The
control and 1000 mg/L were prepared with three replicates whereas the 10
and 100 mg/L treatments were prepared as single replicates.
Additionally, for each concentration and replicate of the test item
assay and of the reference concentrations a nitrification control with
ATU was prepared. Since statistical significant effects were observed
for the range-finding test at the highest test item concentration a main
test was performed with the following concentrations: 9.54, 30.5, 97.7,
312.5 and 1000 mg/L. All test item concentrations were performed with
three replicates whereas the control was performed with six replicates.
Additionally a second test setup was prepared and ATU was added to each
mixture of one set. The test item had a toxic effect on the nitrifying
microorganisms at the highest concentration tested (1000 mg/L). Hence,
the EC50 of the test item for the nitrifying organisms was estimated to
be ≥ 1000 mg/L and the NOEC was observed to be 312.5 mg/L. No toxic
effects were observed for the total and heterotrophic microorganisms.
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