Registration Dossier
Registration Dossier
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EC number: 938-445-6 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- HERA report on Alcohol Sulphates
- Author:
- A.I.S.E. and Cefic
- Year:
- 2 002
- Bibliographic source:
- http://www.heraproject.com/files/3-HH-04- HERA AS HH web wd.pdf
Materials and methods
- Principles of method if other than guideline:
- No guideline exists for this type of appraisal.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H26O4S.Na
- IUPAC Name:
- sodium dodecyl sulfate
- Reference substance name:
- erythromycin salt of hexadecylsulfate
- IUPAC Name:
- erythromycin salt of hexadecylsulfate
- Test material form:
- not specified
Constituent 1
Constituent 2
- Radiolabelling:
- other: partly
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1. Dermal penetration of 14 C-labeled C 12 ASO4 Na (sodium lauryl sulfate) in guinea pigs amounted to 0.35 % of the applied
dose of 3 µmol. This value was obtained by comparison of the total amount excreted after i.p. or dermal application of the compound.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
Results and discussion
- Absorption in different matrices:
- Absorption by the percutaneous route is limited, however, since anionic surfactants tend to bind to the skin surface (Howes, 1975; Black and Howes, 1980). Early studies with isolated human skin were unable to detect penetration of a homologous series of AS, ranging from C8 to C18 (Blank and Gould, 1961). Animal studies confirmed a low level of percutaneous absorption of AS. Less than 0.4% of a 3 µmol dose of 35S-labeled C12AS-Na was percutaneously absorbed in guinea pigs, based on recovery of the radiolabel in urine, faeces and expired air (Prottey and Ferguson, 1975). Studies with rats indicated that pre-washing of the skin with surfactant enhanced AS skin penetration (Black and Howes, 1980).
For consumer exposure, actual dermal absorption is below 1% (Rice, 1977) or very low (Schäfer and Redelmeier, 1996). Taking into account read across uncertainties a default assumption of 10% dermal absorption was taken for deriving the DNEL. Since the dermal absorption decreases with increasing concentration of a solution this percentage can be expanded to workers as a worst case approach.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
