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EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
All relevant information on results is provided in the sections above.
The acute inhalative toxicity of charcoal (Probe 2: C-Fix=80.5%) was investigated in a study in rats that was performed according to OECD guideline no. 403, EU method B.2 and the US EPA Health Effects Test guideline OPPTS 870.1300, Acute Inhalation Toxicity, as per August 1998.
In this study, a group of 10 Wistar Crl:(WI) BR rats (5 males and 5 females) was exposed to an aerosol atmosphere. The animals were exposed for 4 h using a nose-only exposure system, followed by a 14-d observation period.
The mean achieved concentration of charcoal in the exposure was 4.968 mg/L (standard deviation: 3.624 mg/L; nominal concentration: 18.2 mg/L)
The characteristics of the test atmosphere were as follows: Mean mass median aerodynamic diameter (MMAD) (mm): 3.52 µm; geometric standard seviation: 2.46; inhalable fraction (< 4 µm): 52.3%
No death occurred in the test animals.
In males, test item related clinical signs were found between the third hour of inhalation exposure and first hour of observation period. All animals were symptom –free on first day of observation period.
In females animals, test item related clinical signs were found between the third hour of inhalation exposure and first hour of observation period. All female animals were symptom–free from first day of observation period.
The clinical signs represented the decreased activity and general reaction and dyspnoea.
In both genders, body weight loss was observable on the day of inhalation exposure. In both sexes, a compensation of body weight loss was found from third day of observation period.
On basis of body weight and body weight gain data, there was no notable test item effect observable in the exposed animals.
In conclusion, a single 4-h nose-only exposure to charcoal sample Probe 2 to CRL: (WI) BR rat followed by a 14-day observation period at a dose level 5 mg/L was not associated with mortality or any test item-related toxicological findings on the male and female animals.
Accordingly, the acute inhalation median lethal concentration (4-h LC50) of charcoal rats was therefore considered to be greater than 4.97 mg/L.
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