Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summary report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- I U C L I D D a t a s e t Substance ID: 68334-30-5
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- I U C L I D D a t a s e t Substance ID: 68334-30-5 pag 394
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Six groups, each containing 5 male and 5 female Sprague–Dawley rats, were exposed for 4 hours to atmospheric concentrations of 0, 3.5, 3.6, 4.0, 6.9 and 7.3 mg/l of test substance. Atmospheric concentrations were a mixture of aerosol and vapour, and were monitored. Animals were observed for 14 days after exposure. Main clinical signs were dyspnea and dose–related mortality. At necropsy, the main effects found were inflammatory changes and macroscopic congestion, both in the lungs
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 64742-80-09
- IUPAC Name:
- 64742-80-09
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: mixture of aerosol and vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 0, 3.5, 3.6, 4.0, 6.9 and 7.3 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 4.6 mg/L air
- Based on:
- not specified
- Exp. duration:
- 4 d
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
