Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: summary report
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
I U C L I D D a t a s e t Substance ID: 68334-30-5
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
I U C L I D D a t a s e t Substance ID: 68334-30-5 pag 394

Materials and methods

Test guideline
Qualifier:
no guideline available
Deviations:
not specified
Principles of method if other than guideline:
Six groups, each containing 5 male and 5 female Sprague–Dawley rats, were exposed for 4 hours to atmospheric concentrations of 0, 3.5, 3.6, 4.0, 6.9 and 7.3 mg/l of test substance. Atmospheric concentrations were a mixture of aerosol and vapour, and were monitored. Animals were observed for 14 days after exposure. Main clinical signs were dyspnea and dose–related mortality. At necropsy, the main effects found were inflammatory changes and macroscopic congestion, both in the lungs
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
other: mixture of aerosol and vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 4 h
Concentrations:
0, 3.5, 3.6, 4.0, 6.9 and 7.3 mg/l
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
ca. 4.6 mg/L air
Based on:
not specified
Exp. duration:
4 d

Applicant's summary and conclusion