Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Draize test
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summary study report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON Distillate fuel oils
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON Distillate fuel oils pag 43-44
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Four male and 5 female rabbits were used in this study. 0.1 ml of undiluted test material was placed on the everted lower eyelid of the right eye of each rabbit. The left eyes were not treated and served as controls. 30 seconds after application, the eyes of 3 rabbits (2 females, one male) were flushed for one minute with warm distilled water. Scoring for ocular lesions was done at 24, 48 and 72 hours after treatment using the Draize scale. Fluorescein was used to aid evaluation at the 24 hour reading.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- API 79-6
- IUPAC Name:
- API 79-6
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eyes were not treated and served as controls
- Duration of treatment / exposure:
- 30 seconds
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 10
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: All rabbits scored zero at every observation period. Those rabbits that had their eyes rinsed appeared no different to the unrinsed group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
