Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: summary report
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
I U C L I D D a t a s e t Substance ID: 68334-30-5
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
I U C L I D D a t a s e t Substance ID: 68334-30-5 pag 417

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A group of 4 male and 4 female New Zealand White rabbits was tested at a single dose of 2.0 g/kg. The skins of 2 male and 2 female animals were abraded prior to treatment. Animals were observed for 14 days following the 24–hour exposure period. No deaths resulted. At necropsy, reddened and crusted areas were evident at the treatment sites in three animals.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
2 g/kg
No. of animals per sex per dose:
4
Control animals:
not required

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No CL available

Applicant's summary and conclusion