Registration Dossier
Registration Dossier
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EC number: 403-530-4 | CAS number: 129423-54-7 PV-ECHTGELB HGR
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in compliance with GLP standards according to Guideline OECD 402. However, full study report is not available as the data is > 12 year old and summaries have been prepared using data provided by ECHA.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.3; OECD 402(1987)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate
- EC Number:
- 403-530-4
- EC Name:
- Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate
- Cas Number:
- 129423-54-7
- Molecular formula:
- C17H13CaClN4O7S2
- IUPAC Name:
- calcium 4-chloro-5-methyl-2-{2-[3-methyl-5-oxo-1-(3-sulfonatophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazen-1-yl}benzene-1-sulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Vehicle:
- other: angeteigt mit PE-Giykol 400 im Verhaltnis 1 g Substanz + 2 ml PEG 400
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Gross pathology:
- No anomalies
- Other findings:
- Sign of toxicity (local):
No sign of poisoning occured during the entier test period. The skin of the animals was discoloured light yellow one day p.a.
Mortality did not occur
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study was carried out in compliance with GLP according to guideline OECD 402. The LD50 is > 2000 mg/kg bw.
- Executive summary:
No systemic toxic effects were described after single oral application at the dose level 2000 mg/kg in rats. No signs of poisoning occurred during the entire test period. The skin of the animals was coloured light yellow for one day after administration.
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