Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 939-408-7 | CAS number: 85049-86-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study. Only basic data given.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Limited information concerning test conditions and/or experimental methods.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H26O4S.Na
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): Sodium laurylsulfate- Physical state: White powder- Analytical purity: >98% a.i.- Lot / Batch No. : 68/3- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- no data
- No. of animals per sex per dose:
- 5-10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 977 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 427 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Occurred, but no detailed data.
- Clinical signs:
- other: Diarrhoea, spastic gait, decreased activity, lateral position, hunched posture, laboured respiration, coma, death.
- Gross pathology:
- Necropsy of died animals: haemorrhages in gastro-intestinal tract and vascular congestion in the liver
Necropsy of survivors: no adverse effects - Other findings:
- Not stated.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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