Registration Dossier
Registration Dossier
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EC number: 206-341-3 | CAS number: 329-01-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolyl isocyanate
- EC Number:
- 206-341-3
- EC Name:
- α,α,α-trifluoro-3-tolyl isocyanate
- Cas Number:
- 329-01-1
- Molecular formula:
- C8H4F3NO
- IUPAC Name:
- 1-isocyanato-3-(trifluoromethyl)benzene
- Reference substance name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- IUPAC Name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- Details on test material:
- Test substance: Hoechst substance 100 % purity
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- < 87 mg/m³ air
- Exp. duration:
- 4 h
Any other information on results incl. tables
Result : 70 % mortality, serious damage of the lungs.
Applicant's summary and conclusion
- Executive summary:
In a guideline study according OECD 403 rats inhaled an arosol (vapour inhalation) of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate.
LC50 < 87 mg/m³.
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