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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: 5 applications
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1974
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α,α-trifluoro-3-tolyl isocyanate
EC Number:
206-341-3
EC Name:
α,α,α-trifluoro-3-tolyl isocyanate
Cas Number:
329-01-1
Molecular formula:
C8H4F3NO
IUPAC Name:
1-isocyanato-3-(trifluoromethyl)benzene
Constituent 2
Reference substance name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
IUPAC Name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
Details on test material:
Test substance: Hoechst substance 99.47% purity

Test animals

Species:
rabbit
Strain:
other: Russian White
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 times during 5 days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
100%, 10%, 5%, 1%
Basis:
other: concentration of applied test material
No. of animals per sex per dose:
6 animals per concentration
Control animals:
other: not required

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.

Applicant's summary and conclusion

Executive summary:

On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.