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EC number: 206-341-3
CAS number: 329-01-1
A not assignable oral repeated dose study in mice cited from ECB IUCLID Dataset ID: 329-01-1, and repeated inhalation studies in rats and mice from a secondary source (only abstract available; original reference in Russian) are available. Additionally results froma secondary source on dermal toxicity (skin effects) are cited.
In the oral repeated dose sutdy the test substance was applied by
introduction in the stomach in doses of 1/5, 1/10, and
1/20 LD50 (total cumulative dose= 4.5 times LD50; LD50= 975
mg/kg in rat and mouse) did not provoke the death of animals; an
increasing excitement, body weight loss, and respiratory effects were
observed. A NO(A)EL was not stated.
The test substance alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was
studied on rats and mice which were kept for 4 or 2.5 month,
respectively with periodic introduction of
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl.
chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³. At 11.2 mg/m³
the test substance causes functional and histological changes in lungs,
liver kidneys, heart, and brain; at 1.3 mg/m³ the test substance is
nontoxic for rats and mice. All symptoms of poisoning disappear within 3
months after the experiments are ceased.
Undiluted and as a 10% solution the test substance applied on 5 days
once daily induced a pronounced redness with strong skin wrinkles and
dryness of skin. A dilution of 5% revealed only for 24 hours a slight
rednesson 3 animals. A dilution of 1% exhibited no relevant skin
The oral repeated toxicity study was disregared due to the insufficient
documentation of the method and the insufficient information of results.
Due to the results of the dermal and inhalation studies a classification
is not justified.
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