Registration Dossier

Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Guideline compliant well documented study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
no
Type of method:
thermal analysis
Key result
Melting / freezing pt.:
200 °C
Remarks on result:
other: That this effect is the melting of the test item (main component) was verified by subsequent tests with the Kofler-heating bank and with the melting in a capillary.

The test item Sodium dicyclohexyl sulfosuccinate shows a melting of crystalline subcomponents at 200 °C (in the 2nd and 3rd heating run) according to the definition in the OECD Guideline 102 (mean value from repeat determinations; 1st melting from the sub component).

·        200 °C (from first measurement)

·        200 °C (from second measurement)

·        200 °C (from third measurement)

That these effect is the melting of the test item (main component) was verified by subsequent tests with the Kofler-heating bank and with the melting in a capillary.

The cooling run shows a crystallization at 170 °C.

Conclusions:
melting point = 200 °C
Executive summary:

In the Klimisch 1 non-GLP study from Kintrup (2012) the melting point of Sodium dicyclohexyl sulfosuccinate was determined with the DSC method according to OECD 102 and EU method A.1. The test item melted at 200°C. Decomposition was not observed.

For the risk assessment a melting point of 200°C will be used.

This information is considered to be relevant and reliable for the further risk assessment.

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Guideline compliant study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
no
Type of method:
other: DSC

Table 1 – Melting Point / Melting Range of Test Substance by DSC

Specimen No.

Heat Cycle

Onset

(Melting Point)

(°C)

Peak (°C)

Endset (°C)

Melting Range (°C)

Enthalpy (joules/g)

1

1

199.4

207.1

213.2

199 - 213

59

2

1

199.7

206.9

211.4

200 – 211

68

1

2

199.9

204.6

207.8

200 – 208

42

2

2

199.8

204.6

207.8

200 - 208

45

 

Conclusions:
melting point = 199.8 °C
Executive summary:

The melting point of the test substance was determined using a Mettler 821e DSC. Test was performed with a pierced lid in order to remove any residual moisture as sample is hydroscopic. Test substance specimens were scanned at 10°C/min from 100°C to 225°C for both heat cycles. However, a 20 minute isotherm was performed before each step in order to dry the specimens. An indium standard was used to calibrate the instrument. The standard was also scanned at 10°C/min. The melting point is 199.8°C. The method has an estimated accuracy of ±0.5°C. 

Description of key information

melting point: 200°C

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
200 °C

Additional information

In the Klimisch 1 non-GLP key study from Kintrup (2012) the melting point of Sodium dicyclohexyl sulfosuccinate was determined with the DSC method according to OECD 102 and EU method A.1. The test item melted at 200°C. Decomposition was not observed.

In the supporting study the melting point of the test substance was determined in the Cytec non GLP Klimisch 1 study (Rivera 2011) using DSC. Test was performed with a pierced lid in order to remove any residual moisture as sample is hydroscopic. Test substance specimens were scanned at 10°C/min from 100°C to 225°C for both heat cycles. However, a 20 minute isotherm was performed before each step in order to dry the specimens. An indium standard was used to calibrate the instrument. The standard was also scanned at 10°C/min. The melting point is 199.8°C. The method has an estimated accuracy of ±0.5°C. 

Both studies determined virtually the same melting temperature. Both studies have high quality. The mean of both studies is 200°C. For the risk assessment a melting point of 200°C will be used.

The test result is considered relevant and reliable for the risk assessment.