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EC number: 204-534-7 | CAS number: 122-32-7
According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met.
Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”.
Since the group concept is applied to the members of the Glycerides category, data will be generated from a representative category member to avoid unnecessary animal testing. Additionally, once the group concept is applied, substances will be classified and labelled on this basis.
Classification related key information
Biodegradation in water: screening tests: 76.5% in 28 days (OECD 301B).
Bioaccumulation: No significant bioaccumulation in biota is expected for this substance (see IUCLID section 5.3).
LC50 (48 h)(Leuciscus idus): > 1000 mg/L (nominal)(German method).
EL50 (48 h)(Daphnia magna): > 100 mg/L (nominal)(read-across)(OECD 202).
IC50 (72 h)(Selenastrum capricornutum): > 5 mg/L (nominal)(EPA 600/4-89/001).
NOELR (21 d)(Daphnia magna): ≥ 10 mg/L (nominal, loading rate)(read-across)(OECD 211).
NOEC (72 h)(Selenastrum capricornutum): ≥ 5 mg/L (nominal)(EPA 600/4-89/001).
Non-classification justification according to CLP
Based on the data above, 1,2,3-propanetriyl trioleate (CAS No. 122-32-7) is considered to be rapidly degradable and have low potential for bioaccumulation. The acute L(E)C50 values reported for fish, aquatic invertebrates and algae are > 1 mg/L.Therefore,1,2,3-propanetriyl trioleate does not need to be classified and labelled as acute aquatic hazard according to the 2nd ATP of Regulation (EC) No.1272/2008 (CLP).
Valid chronic toxicity data are available, with NOEC values (aquatic invertebrates and algae) > 1 mg/L.Thus,1,2,3-propanetriyl trioleate does not need to be classified and labelled as long-term aquatic hazard according to the 2nd ATP of Regulation (EC) No.1272/2008 (CLP).
Non-classification justification according to DSD
Based on the data above, 1,2,3-propanetriyl trioleate (CAS No. 122-32-7) is considered to be rapidly degradable and have low potential for bioaccumulation. The acute L(E)C50 values reported for fish, aquatic invertebrates and algae are > 1 mg/L. Considering this information, 1,2,3-propanetriyl trioleate does not need to be classified and labeled as environmental hazard according to Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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