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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.

Key value for chemical safety assessment

Additional information

According to Regulation (EC) No. 1907/2006, Annex IX, Column 2, 9.1.6, long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. 1,2,3-propanetriyl trioleate (CAS No. 122-32-7) is a readily biodegradable and poorly soluble substance (< 0.05 mg/L). Due to these characteristics, extensive biodegradation and adsorption to activated sludge within conventional STPs can be expected and therefore, only low concentrations, if any, are likely to be released into the water phase. Fish exposure to this substance is thus expected to be low. Furthermore, the acute fish tests conducted with the substance and a structurally related analogue (in accordance with Regulation (EC) No. 1907/2006, Annex XI, section 1.5), showed no mortality or sub-lethal effects after 48 hours of exposure. The study available for algae also showed no toxicity up to the limit of water solubility (EC50 (72 h) > 5 mg/L, nominal concentration). Additionally, a chronic test performed on aquatic invertebrates according to OECD 211 is available for an analogue substance showing no effects on either mortality or reproduction endpoints (NOELR (21 d) ≥ 10 mg/L).

Based on the short term values, fish cannot be identified as the most sensitive organism. According to the Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2008), long-term toxicity testing on fish should only be conducted if it represents the most sensitive taxonomic group. The Guidance states that if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish. Considering this information, long-term toxicity testing on fish species is not deemed necessary.