Registration Dossier
Registration Dossier
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EC number: 234-974-5 | CAS number: 12047-11-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.15 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 200
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Based on experimental studies results, the inhaled barium hexaferrite powder can be retained in the lungs for a long time period. Inside the lungs, the substance can cause adverse local effects as fiber deposition and subsequently pneumoconiosis.
Therefore, a specific DNEL is established in order to characterize the risk for the long-term inhalation exposure.
Experimental data show that inhaled barium hexaferrite powder may induce pneumoconiosis (identified as critical effect) following repeated exposure at concentration higher than 30 mg/m3 (NOAEC). Starting from this value, a DNEL of 0,15 mg/m3 was derived using an assessment factor of 200 calculated as follows:
- 10 for intraspecies variability
- 10 for interspecies variability
- 2 for accounting of differences in daily duration of exposure (4 h/day in animals, 8 h/day workers).
Whilst the substance is acutely hazardous by inhalation (it is classified as STOT SE 2), a reliable D(M)NEL cannot be identified from the available data. The information has to be intended as a qualitative indication which allows to adopt all suitable risk management measures in case of incidents or massive substance releases.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The substance is provided to general population within articles (as polymer bonded magnet), which do not foresee any substance release. Consequently, general population exposure is not expected and no D(M)NEL has to be derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
