Registration Dossier
Registration Dossier
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EC number: 416-530-4 | CAS number: 178949-82-1
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-04-23 to 1993-05-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Medium:
- standard fat
- Solubility:
- <= 0.4 mg/100 g solvent
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Conclusions:
- In a GLP study conducted according to OECD Guideline 106, the solubility of trisodium EDDS in a standard fat was up to 4 mg/kg at 37°C
- Executive summary:
In a GLP study conducted according to OECD Guideline 106, the solubility of trisodium EDDS in a standard synthetic fat (HB307) was determined by stirring the test material (100 or 400 mg) with the fat solvent (50 or 25 mL respectively) at 37oC for up to 48 h. The concentration of the test material in the fat phase was measured by HPLC.
The analysed concentrations of trisodium EDDS varied from 0.09 to 3.57 mg/kg. Due to the significant variation between measurements, the fat solubility was taken to be equal to or less than 3.57 mg/kg (the highest concentration analysed).
Reference
Description of key information
In a GLP study conducted according to OECD Guideline 106, the solubility of trisodium EDDS in a standard fat was up to 4 mg/kg at 37°C.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 0.4
- At the temperature of:
- 37 °C
Additional information
In a GLP study conducted according to OECD Guideline 106, the solubility of trisodium EDDS in a standard synthetic fat (HB307) was determined by stirring the test material (100 or 400 mg) with the fat solvent (50 or 25 mL respectively) at 37oC for up to 48 h. The concentration of the test material in the fat phase was measured by HPLC.
The analysed concentrations of trisodium EDDS varied from 0.09 to 3.57 mg/kg. Due to the significant variation between measurements, the fat solubility was taken to be equal to or less than 3.57 mg/kg (the highest concentration analysed) (de Vries, 1993c).
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