Registration Dossier
Registration Dossier
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EC number: 416-530-4 | CAS number: 178949-82-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-04-26 to 1993-04-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 1 000 g/L
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- HPLC analysis of duplicate aliquots of the 1:1 (w/v) solution gave concentrations of 1039 and 1042 g/L
- Conclusions:
- Very soluble (> 10000 mg/L)
In a GLP study conducted according to OECD Guideline 105, trisodium EDDS is very soluble in water (>1000 g/L) at 20°C. - Executive summary:
In a GLP study conducted according to OECD Guideline 105, the solubility of trisodium EDDS was determined by shaking 25 g (solid) with 25 mL double distilled water overnight at room temperature. A single colourless phase was seen with concentrations of trisodium EDDS in duplicate aliquots determined as 1039 and 1042 g/L by HPLC. Trisodium EDDS is very soluble in water (>1000 g/L) at 20°C.
Reference
Description of key information
In a GLP study conducted according to OECD Guideline 105, trisodium EDDS is very soluble in water (solubility > 1000 g/L) at 20°C
Key value for chemical safety assessment
- Water solubility:
- 1 000 g/L
- at the temperature of:
- 20 °C
Additional information
In a GLP study conducted according to OECD Guideline 105, the solubility of trisodium EDDS was determined by shaking 25 g (solid) with 25 mL double distilled water overnight at room temperature. A single colourless phase was seen with concentrations of trisodium EDDS in duplicate aliquots determined as 1039 and 1042 g/L by HPLC. Trisodium EDDS is very soluble in water (solubility > 1000 g/L) at 20°C (de Vries, 1993b).
In addition, in a GLP study conducted according to EU Method A.6, the water solubility of EDDS acid was calculated as moderately soluble (0.15 g/L) (Gair et al. 2002). [Data on EDDS free acid is considered relevant to use for understanding the water solubility of trisodium EDDS, and is acceptable for using as read-across information.]
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