Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl 2-methoxy-4-prop-1-enylphenyl ether
EC Number:
204-370-6
EC Name:
Benzyl 2-methoxy-4-prop-1-enylphenyl ether
Cas Number:
120-11-6
Molecular formula:
C17H18O2
IUPAC Name:
benzyl 2-methoxy-4-prop-1-enylphenyl ether

Results and discussion

Water solubility
Key result
Water solubility:
0.67 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 10 - <= 11

Applicant's summary and conclusion

Conclusions:
The BENZYL ISO EUGENOL solubility in water at 20 ± 0.5 °C based on the mean of the two determinations with the column elution method was 0.670 mg/L.
Executive summary:

A study was performed to assess the water solubility of the test item BENZYL ISO EUGENOL by the column elution method.

This method is based on the elution of the test item with water from a micro-column charged with an inert support material (celite), previously coated with an excess of the test item. The water solubility was given by the mass concentration of the eluate when this has reached a plateau as a function of time. A second experiment was performed at half the flow rate. The test item concentration was regularly measured by HPLC-DAD.

The BENZYL ISO EUGENOL solubility in water at 20 ± 0.5 °C based on the mean of the two determinations with the column elution method was             0.670 mg/L.